Accepted:
20 Dec 2003
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/vol10/huen02/ | © Copyright 2002 | |||
| Volume 10 | Received: Accepted: |
25 Oct 2001 20 Dec 2003 |
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Protein sequence instability: a mathematical analysis
Huen, Y. K. |
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| Abstract | |
| The general theory of k-nary strings has been developed by the author in several online papers but the study has not been extended to protein sequences. DNA can be treated as 4-nary strings which by theorem 12 (see Appendix) is always unstable. Likewise protein sequences can be treated as 20-nary strings which are also unstable. Thus the theory of genomic instability can be extended to include the theory of protein instability. Compressibility Ratio or Comprat as a unit of measure for genomic instability can now be extended to cover protein instability. Genomic stabilisation by junkDNA has its parallel in protein stabilisation by junkProteins or jPrP. The paper reports findings on the string instability profile of Bovine Prion Protein under protein stabilisation by junkProteins. The probability of a prion being docked by a random jPrP with lengths ranging from 10 to 20 amino-acids is investgated. It shows that the probability is not low enough to be ignored when viewed over a period from 10 to 30 years for the disease to manifest. | |
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Multimedia Links (none) Reference Links Citation Reference Huen, Y. K. (2002), Protein sequence instability: a mathematical analysis, Complexity International, Volume 10, Paper ID: huen02, URL: http://www.complexity.org.au/ci/vol10/huen02/ |
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