One-Dimensional Strobomaps and Coherence Analysis of Human Depth EEG During Seizure Activity.

		/vol03/kloppcs96/	© Copyright 1996
		Volume 03	Received: Accepted:	---- ----

One-Dimensional Strobomaps and Coherence Analysis of Human Depth EEG During Seizure Activity. John Klopp, Valeriy I. Nenov & Cameron Jones
Abstract
	Neuronal systems are capable of generating electroencephalographic (EEG) signals with high-dimensional nonlinear dynamics. Patients with complex partial epilepsy sometimes undergo depth EEG monitoring for pre-surgical localisation of seizure onset. Stroboscopic and coherence mapping, two novel approaches for EEG analysis, were applied to depth EEG seizure data from two patients. Multiple time-lagged one-dimensional strobomaps were derived from phase plots of seizure data. Negative correlation values between V(n) and V(n+1) in strobomaps reached -0.97 during seizure activity from the right amygdala of one patient. Although not indicative of deterministic chaos, this suggests non-random, low frequency modulation of neural group activity during seizures. Characteristic patterns of coherence fluctuation also occurred during seizure episodes. Further analysis that incorporates the full spatial distribution of all available data may uncover chaos hidden in the ensemble of electrical seizure activity within the human brain. Signature patterns of stroboscopic or coherence measures associated with specific seizure stages could aid in elucidating the neural substrates of epileptogenesis. However, the clinical value of this information has yet to be determined.

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